Sutro's at the cliff house is one of my faves and very iconic.
http://www.cliffhouse.com (take the time to watch the intro)
The Tadich grill is also one of my favorites. Also very iconic. Their website isn't much but the food is delicious.
http://www.tadichgrill.comYou might also explore North beach for some good Italian food. The stinking rose comes to mind but there are plenty of good resturaunts to choose from. Or if you just want drinks you might try Vesuvios right next to city lights bookstore. 255 Columbus ave @ Jack Kerouac alley
http://www.vesuvio.com Both the book store and the cafe/bar are once again... very Iconic.