At the risk of being naive/overly simplistic....if the Panigale is using something very similar to the GP "frame" then that must be the biggest constraint on performance, cause the GP engine is much more powerful than the Panigale engine.
The Panigale is using the previous generation GP frame, or frameless, design.
The new GP is a traditional Aluminum box/rail frame ala Japanese style.
The Panigale needs to dominate Superstock if not WSBK to prove the dedication to the technology that failed in GP.
Many feel the GP 90deg V is the problem. In the end, Ducati just can't make the front tire stick like Honda or Yamaha.
The new GP crew should, if all goes well, have enough data to produce a better frame say midyear or for next year at least. Audi is finally making changes that make sense, that Ducati never would, ie moving Prezioso off the program.
But if the Panigale fails, it all goes back to that man and his 'vision' of the Ducati GP/SBK.